Author(s):
1. Dijana Jelić, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina
2. Aleksandra Šmitran, University of Banja Luka, Medical Faculty, Republic of Srpska, Bosnia and Herzegovina
3. Sanja Šehovac, Prirodno-matematički fakultet Banja Luka, Republic of Srpska, Bosnia and Herzegovina
4. Savka Janković, Prirodno-matematički fakultet Banja Luka, Republic of Srpska, Bosnia and Herzegovina
5. Dragana Gajić, Prirodno-matematički fakultet Banja Luka, Republic of Srpska, Bosnia and Herzegovina
6. Mladena Malinović, Prirodno-matematički fakultet Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Abstract:
Last decade is designated as the postantibiotic era due to increasing number of resistant and multiresistant strains of microorganism which show resistance to one or more antibiotics. Antimicrobial resistance becomes a global health problem. This phenomenon of antimicrobial resistance will undoubtedly affect the efficiency and use of antibiotics in the future. Science and technological development are committed to researching and developing new antibiotics that will satisfy the missing criteria and address the problem of antimicrobial resistance. One of the possible solutions lies in nanotechnologies. Nanoparticles have been isolated as one of the most promising substances on which microorganisms rarely or even develop mechanisms of resistance. The nanoparticles may be in conjunction with already existing antibiotics structures and contribute to the improvement of physicochemical properties in order to successfully overcome the mechanism of antimicrobial resistance or nanoparticles may themselves be an antitumour agent such as colloidal silver, zinc, ferrum, copper, titanium or vanadium. By designing nanoparticles with proper physicochemical and biochemical characteristic we determine their application. The aim of this research is to synthesized ferrum oxide nanoparticles dopped with copper ions in order to test their antimicrobial acitivity and to evaluate their use as potential antimicrobial agent. Extracts of green and black tea were used as reduction agent for the Fe oxide nanoparticles dopped with Cu. The antimicrobial sensitivity of the synthesized nanoparticles on the isolates Acinetobacter baumannii and methicillin resistant Staphylococcus aureus (MRSA) was performed by the diffusion method on the Muller-Hinton substrate. Synthesized ferrum oxide nanoparticles showed sensitivity toward Acinetobacter baumannii with inhibition zone around 12mm. Photocatalytical activity was also evaluated by UV/VIS spectrophotometry. Samples dopped with copper showed better photocatalytical perfomances.

Key words:
nanoparticles,antimicrobial resistance,ferrum oxide,photocatalytical

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
02.08.2019.

Conference:
Contemporary Materials 2019 - Savremeni Materijali