Author(s):
1. Barbara Stanimirović, klinicki centar republike srpske, Republic of Srpska, Bosnia and Herzegovina
2. Dejan Pejić, JZU Bolnica Gradiška, Republic of Srpska, Bosnia and Herzegovina
3. Jelena Mrđa, klinicki centar republike srpske, Republic of Srpska, Bosnia and Herzegovina
4. Dragi Stanimirović, klinicki centar republike srpske, Republic of Srpska, Bosnia and Herzegovina

Abstract:
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children and is one of the most common chronic disease of childhood. Lack of specific diagnostic, prognostic or response to treatment markers in JIA leads to study new potential markers, as serum calprotectin. This heterodimer, part of the S100 protein family, is directly released by activated leukocytes during inflammation, and stimulates transendothelial migration of phagocytes at the site of inflammation. At present, according to many authors it is considered that calprotectin is a potentially more sensitive biomarker of the disease activity in rheumatoid disorders than conventional inflammatory biomarkers such as the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), because it directly reflects inflammation in the synovium. Evidence of the existence of new markers of inflammation, the development and application of techniques for their use in everyday clinical practice, give new opportunities in early detection and monitoring of children with JIA, which will influence better control of the disease and improving the quality of life.

Key words:
artritis, inflamacija, kalprotektin

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
31.07.2017.

Conference:
Contemporary Materials 2017 - Savremeni Materijali